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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 54-year-old male patient (BSA = 1.8 m2) is being treated for head and neck cancer with the following regimen:
* Cisplatin 100 mg/m2 intravenously on day 1
* 5-Fluorouracil 1000 mg/m2 intravenously by continuous infusion on days 1 through 5
* Ondansetron 16 mg intravenously
Which of the following is the appropriate administration instruction for ondansetron?

A) Thirty minutes prior to Cisplatin, thereafter as needed for nausea
B) Daily prior to 5-fluorouracil infusion on days 1 through 5
C) One dose 30 minutes before Cisplatin and a repeat dose immediately before 5- fluorouracil on day 1; then repeat daily before 5-fluorouracil
D) Thirty minutes before Cisplatin on day 1

2. A 58-year-old woman presents to the emergency department of a small rural hospital with recurrent chest pain that is unrelieved by three sublingual nitroglycerin tablets. Initial evaluation of her ECG and cardiac enzymes are consistent with non-STEMI. The woman is admitted for observation and given aspirin. Which of the following should be added to this patient's regimen to reduce her risk of death, MI, and recurrent ischemia?

A) Oral warfarin
B) Subcutaneous heparin
C) Intravenous t-PA
D) Subcutaneous enoxaparin

3. The risk of methemoglobinemia is highest with the use of:

A) benzocaine 20% topical cream in a 42-year-old for pain associated with insect bites.
B) benzocaine 7.5% oral gel in an 18-month-old for oral pain associated with teething.
C) benzocaine 6% topical cream in a 25-year-old for pain associated with a sunburn.
D) benzocaine 10% oral gel in a 67-year-old for oral pain associated with ill-fitting dentures.

4. A patient with renal failure is being treated with phenytoin and has an albumin concentration of
1.7 g/dL. Which of the following is likely to be higher than the general population in this patient?

A) Maintenance dose
B) Total steady-state phenytoin concentration
C) Free fraction of phenytoin
D) Loading dose

5. A 60-year-old patient has a 15-year history of type 2 diabetes mellitus, hypertension, and dyslipidemia. The patient, who denies smoking or drinking, complains of early satiety, a full feeling, bloating, and vomiting, for the past 2 months. Current medications include glipizide, metformin, and atorvastatin. The most recent A1C was 9.8%. Liver and renal function test results are within normal limits.
Which of the following would be most appropriate for managing these complaints?

A) Begin intravenous fluids.
B) Discontinue metformin.
C) Start metoclopramide.
D) Start simethicone.

Solutions: